Article
Alkaline-shifted pHo sensitivity of AE2c1-mediated anion exchange reveals novel regulatory determinants in the AE2 N-terminal cytoplasmic domain.
The Journal of biological chemistry - 27 Jan 2006
Kurschat Christine E, Shmukler Boris E, Jiang Lianwei, Wilhelm Sabine, Kim Edward H, Chernova Marina N, Kinne Rolf K H, Stewart Andrew K, Alper Seth L
Abstract excerpt
The mouse anion exchanger AE2/SLC4A2 Cl(-)/HCO(-)(3) exchanger is essential to post-weaning life. AE2 polypeptides regulate pH(i), chloride concentration, cell volume, and transepithelial ion transport in many tissues. Although the AE2a isoform has been extensively studied, the function and regulation of the other AE2 N-terminal variant mRNAs of mouse (AE2b1, AE2b2, AE2c1, and AE2c2) have not been examined. We...
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