Article
Cerebellum development and schizophrenia: an association study of the human homeogene Engrailed 2.
Psychiatry research - 30 Apr 2004
Gourion David, Leroy Sophie, Bourdel Marie-Chantal, Goldberger Céline, Poirier Marie-France, Olié Jean-Pierre, Krebs Marie-Odile
Abstract excerpt
Epidemiological data and family studies in schizophrenia show that genetic factors contribute to the vulnerability to this disorder. The homeogene Engrailed 2 (EN2) is specifically involved in patterning the region that gives rise to the cerebellum and controls the plasticity of midbrain dopaminergic neurons. We carried out an association study for a CA repeat polymorphism located in the 3' region of the...
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