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Article

Autism associated gene, engrailed2, and flanking gene levels are altered in post-mortem cerebellum.

PloS one - 1 Jan 2014

Choi Jiyeon, Ababon Myka R, Soliman Mai, Lin Yong, Brzustowicz Linda M, Matteson Paul G, Millonig James H

Abstract excerpt

BACKGROUND: Previous genetic studies demonstrated association between the transcription factor engrailed2 (EN2) and Autism Spectrum Disorder (ASD). Subsequent molecular analysis determined that the EN2 ASD-associated haplotype (rs1861972-rs1861973 A-C) functions as a transcriptional activator to increase gene expression. EN2 is flanked by 5 genes, serotonin receptor5a (HTR5A), insulin induced gene1 (INSIG1),...

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Source

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Identifiers

PMID: 24520327
DOI: 10.1371/journal.pone.0087208
PMCID: PMC3919719

Genes

SHH
CNPY1
INSIG1
RBM33

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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