Article
Association of the ENGRAILED 2 (EN2) gene with autism in Chinese Han population.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jun 2008
Wang Lifang, Jia Meixiang, Yue Weihua, Tang Fulei, Qu Mei, Ruan Yan, Lu Tianlan, Zhang Handi, Yan Hao, Liu Jing, Guo Yanqing, Zhang Jishui, Yang Xiaoling, Zhang Dai
Abstract excerpt
Human ENGRAILED 2 (EN2) gene is localized to 7q36, an autism susceptibility locus. En2 knockout mice display hypoplasia of cerebellum and a decrease in the number of Purkinje cell, which are similar to those reported for individuals with autism. Furthermore, deficits in social behavior were detected in En2(-/-) mice. Two recent studies have demonstrated that two intronic SNPs (rs1861972, rs1861973) in the EN2...
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