Article
Association of the homeobox transcription factor gene ENGRAILED 2 with autistic disorder in Chinese children.
Neuropsychobiology - 1 Jan 2008
Yang Pinchen, Lung For-Wey, Jong Yuh-Jyh, Hsieh Hsin-Yi, Liang Chung-Ling, Juo Suh-Hang Hank
Abstract excerpt
BACKGROUND: Autism is a neurodevelopmental disorder with a strong genetic component. Previous studies have mapped the disease to chromosome 7q, where the homeobox transcription factor ENGRAILED 2 (EN2) gene is located. EN2 is specifically involved in patterning the region that gives rise to the cerebellum. In the present work, we carried out a case-control study to determine whether 2 intronic single-nucleotide...
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