Initial association of NR2E1 with bipolar disorder and identification of candidate mutations in bipolar disorder, schizophrenia, and aggression through resequencing.

doi:10.1002/ajmg.b.30696

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Initial association of NR2E1 with bipolar disorder and identification of candidate mutations in bipolar disorder, schizophrenia, and aggression through resequencing.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Sept 2008

Kumar Ravinesh A, McGhee Kevin A, Leach Stephen, Bonaguro Russell, Maclean Alan, Aguirre-Hernandez Rosalia, Abrahams Brett S, Coccaro Emil F, Hodgins Sheilagh, Turecki Gustavo, Condon Anne, Muir Walter J, Brooks-Wilson Angela R, Blackwood Douglas H, Simpson Elizabeth M

Abstract excerpt

Nuclear receptor 2E1 gene (NR2E1) resides within a 6q21-22 locus for bipolar disorder and schizophrenia. Mice deleted for Nr2e1 show altered neurogenesis, cortical and limbic abnormalities, aggression, hyperexcitability, and cognitive impairment. NR2E1 is therefore a positional and functional candidate for involvement in mental illness. We performed association analyses in 394 patients with bipolar disorder, 396...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aggression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bipolar Disorder

Share to DNA Mutational Analysis

Share to Genetic Linkage

Share to Microsatellite Repeats

Share to Orphan Nuclear Receptors

Share to Receptors, Cytoplasmic and Nuclear

Share to Schizophrenia

Source

Open in PubMed

Identifiers

PMID: 18205168
DOI: 10.1002/ajmg.b.30696

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Initial association of NR2E1 with bipolar disorder and identification of candidate mutations in bipolar disorder, schizophrenia, and aggression through resequencing.PMID 18205168Read ↗

Genetic analysis of the NR2E1 gene as a candidate gene of schizophrenia.Semantic proximity Read ↗

Mutation and evolutionary analyses identify NR2E1-candidate-regulatory mutations in humans with severe cortical malformations.Semantic proximity Read ↗

Neurexin 1 (NRXN1) deletions in schizophrenia.Semantic proximity Read ↗

Genomic mapping and cellular expression of human CPG2 transcripts in the SYNE1 gene.Semantic proximity Read ↗

Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia.Semantic proximity Read ↗

NR4A2 haploinsufficiency is associated with intellectual disability and autism spectrum disorder.Semantic proximity Read ↗

Evolutionary and functional data power search for obsessive-compulsive disorder genesSemantic proximity Read ↗

A rare variant in D-amino acid oxidase implicates NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorderSemantic proximity Read ↗

Functional variants at 1p36.23 confer risk of schizophrenia through modulating RERE.Semantic proximity Read ↗

De novo variants of NR4A2 are associated with neurodevelopmental disorder and epilepsy.Semantic proximity Read ↗

A report of two novel NR5A1 mutation families: possible clinical phenotype of psychiatric symptoms of anxiety and/or depression.Semantic proximity Read ↗

Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.