Autism-associated haplotype affects the regulation of the homeobox gene, ENGRAILED 2.

doi:10.1016/j.biopsych.2009.05.027

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Article

Autism-associated haplotype affects the regulation of the homeobox gene, ENGRAILED 2.

Biological psychiatry - 15 Nov 2009

Benayed Rym, Choi Jiyeon, Matteson Paul G, Gharani Neda, Kamdar Silky, Brzustowicz Linda M, Millonig James H

Abstract excerpt

BACKGROUND: Association analysis identified the homeobox transcription factor, ENGRAILED 2 (EN2), as a possible autism spectrum disorder (ASD) susceptibility gene (ASD [MIM 608636]; EN2 [MIM 131310]). The common alleles (underlined) of two intronic single nucleotide polymorphisms (SNPs), rs1861972 (A/G) and rs1861973 (C/T), are over-transmitted to affected individuals both singly and as a haplotype in three...

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PMID: 19615670
DOI: 10.1016/j.biopsych.2009.05.027
PMCID: PMC2783416

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