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Article

Genetic subdivision of the tectum and cerebellum into functionally related regions based on differential sensitivity to engrailed proteins.

Development (Cambridge, England) - 1 Jun 2007

Sgaier Sema K, Lao Zhimin, Villanueva Melissa P, Berenshteyn Frada, Stephen Daniel, Turnbull Rowena K, Joyner Alexandra L

Abstract excerpt

The genetic pathways that partition the developing nervous system into functional systems are largely unknown. The engrailed (En) homeobox transcription factors are candidate regulators of this process in the dorsal midbrain (tectum) and anterior hindbrain (cerebellum). En1 mutants lack most of the tectum and cerebellum and die at birth, whereas En2 mutants are viable with a smaller cerebellum and foliation...

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Identifiers

PMID: 17537797
DOI: 10.1242/dev.000620
PMCID: PMC2840613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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