Article
Phosphorylation-regulated transitions in an oligomeric state control the activity of the Sae2 DNA repair enzyme.
Molecular and cellular biology - 1 Mar 2014
Fu Qiong, Chow Julia, Bernstein Kara A, Makharashvili Nodar, Arora Sucheta, Lee Chia-Fang, Person Maria D, Rothstein Rodney, Paull Tanya T
Abstract excerpt
In the DNA damage response, many repair and signaling molecules mobilize rapidly at the sites of DNA double-strand breaks. This network of immediate responses is regulated at the level of posttranslational modifications that control the activation of DNA processing enzymes, protein kinases, and scaffold proteins to coordinate DNA repair and checkpoint signaling. Here we investigated the DNA damage-induced...
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