Article
Sae2p phosphorylation is crucial for cooperation with Mre11p for resection of DNA double-strand break ends during meiotic recombination in Saccharomyces cerevisiae.
Genes & genetic systems - 1 Jun 2008
Terasawa Masahiro, Ogawa Tomoko, Tsukamoto Yasumasa, Ogawa Hideyuki
Abstract excerpt
Meiotic recombination is initiated by the introduction of DNA double-strand breaks (DSBs) at recombination hotspots. DSB ends are resected to yield ssDNA, which is used in a homology search. Sae2p, which is involved in the resection of DSB ends, is phosphorylated by the Mec1p and Tel1p kinases du...
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