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Article

CDK targets Sae2 to control DNA-end resection and homologous recombination.

Nature - 2 Oct 2008

Huertas Pablo, Cortés-Ledesma Felipe, Sartori Alessandro A, Aguilera Andrés, Jackson Stephen P

Abstract excerpt

DNA double-strand breaks (DSBs) are repaired by two principal mechanisms: non-homologous end-joining (NHEJ) and homologous recombination (HR). HR is the most accurate DSB repair mechanism but is generally restricted to the S and G2 phases of the cell cycle, when DNA has been replicated and a sister chromatid is available as a repair template. By contrast, NHEJ operates throughout the cell cycle but assumes most...

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Identifiers

PMID: 18716619
DOI: 10.1038/nature07215
PMCID: PMC2635538

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CDK targets Sae2 to control DNA-end resection and homologous recombination.PMID 18716619Read ↗

Controlling DNA-end resection: a new task for CDKsSemantic proximity Read ↗

Dbf4-dependent kinase promotes cell cycle controlled resection of DNA double-strand breaks and repair by homologous recombinationSemantic proximity Read ↗

The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation.Semantic proximity Read ↗

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Elevated Levels of the Polo Kinase Cdc5 Override the Mec1/ATR Checkpoint in Budding Yeast by Acting at Different Steps of the Signaling PathwaySemantic proximity Read ↗

Human CtIP mediates cell cycle control of DNA end resection and double strand break repair.Semantic proximity Read ↗

Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replicationSemantic proximity Read ↗

Sae2p phosphorylation is crucial for cooperation with Mre11p for resection of DNA double-strand break ends during meiotic recombination in Saccharomyces cerevisiae.Semantic proximity Read ↗

Cdk2 Is Required for p53-Independent G2/M Checkpoint ControlSemantic proximity Read ↗

CSB interacts with BRCA1 in late S/G2 to promote MRN- and CtIP-mediated DNA end resectionSemantic proximity Read ↗

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Cdk1 targets Srs2 to complete synthesis-dependent strand annealing and to promote recombinational repair.Semantic proximity Read ↗

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