CDK targets Sae2 to control DNA-end resection and homologous recombination.

doi:10.1038/nature07215

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Article

CDK targets Sae2 to control DNA-end resection and homologous recombination.

Nature - 2 Oct 2008

Huertas Pablo, Cortés-Ledesma Felipe, Sartori Alessandro A, Aguilera Andrés, Jackson Stephen P

Abstract excerpt

DNA double-strand breaks (DSBs) are repaired by two principal mechanisms: non-homologous end-joining (NHEJ) and homologous recombination (HR). HR is the most accurate DSB repair mechanism but is generally restricted to the S and G2 phases of the cell cycle, when DNA has been replicated and a sister chromatid is available as a repair template. By contrast, NHEJ operates throughout the cell cycle but assumes most...

Topics

Amino Acid Motifs
CDC28 Protein Kinase, S cerevisiae
Cell Cycle
Cell Line
Cell Survival
Conserved Sequence
DNA Breaks, Double-Stranded
DNA Repair
Endodeoxyribonucleases
Endonucleases
Exodeoxyribonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Mutation

Phosphorylation

Phosphoserine

Rad52 DNA Repair and Recombination Protein

Recombination, Genetic

Saccharomyces cerevisiae

Source

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Identifiers

PMID: 18716619
DOI: 10.1038/nature07215
PMCID: PMC2635538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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CDK targets Sae2 to control DNA-end resection and homologous recombination.PMID 18716619Read ↗

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