Article

Structure of the human SAGA coactivator complex: The divergent architecture of human SAGA allows modular coordination of transcription activation and co-transcriptional splicing

2021-02-08

Abstract excerpt

Human SAGA is an essential co-activator complex that regulates gene expression by interacting with enhancer-bound activators, recruiting transcriptional machinery, and modifying chromatin near promoters. Subunit variations and the metazoan-specific requirement of SAGA in development hinted at unique structural features of the human complex. Our 2.9 Å structure of human SAGA reveals intertwined functional modules f...

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Literature Corpus work: cc5f9787-3e95-5ae6-82c7-67d8ccfd6239
DOI: 10.1101/2021.02.08.430339

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