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Article

Recruitment of SWI/SNF by Gcn4p does not require Snf2p or Gcn5p but depends strongly on SWI/SNF integrity, SRB mediator, and SAGA.

Molecular and cellular biology - 1 Dec 2003

Yoon Sungpil, Qiu Hongfang, Swanson Mark J, Hinnebusch Alan G

Abstract excerpt

The nucleosome remodeling complex SWI/SNF is a coactivator for yeast transcriptional activator Gcn4p. We provide strong evidence that Gcn4p recruits the entire SWI/SNF complex to its target genes ARG1 and SNZ1 but that SWI/SNF is dispensable for Gcn4p binding to these promoters. It was shown prev...

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Source

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Identifiers

PMID: 14612422
DOI: 10.1128/MCB.23.23.8829-9945.2003
PMCID: PMC262668

Genes

ARG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14612422-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Recruitment of SWI/SNF by Gcn4p does not require Snf2p or Gcn5p but depends strongly on SWI/SNF integrity, SRB mediator, and SAGA.PMID 14612422Read ↗

Simultaneous recruitment of coactivators by Gcn4p stimulates multiple steps of transcription in vivo.Semantic proximity Read ↗

An array of coactivators is required for optimal recruitment of TATA binding protein and RNA polymerase II by promoter-bound Gcn4p.Semantic proximity Read ↗

A multiplicity of coactivators is required by Gcn4p at individual promoters in vivo.Semantic proximity Read ↗

Continuous and widespread roles for the Swi-Snf complex in transcription.Semantic proximity Read ↗

Essential functional interactions of SAGA, a Saccharomyces cerevisiae complex of Spt, Ada, and Gcn5 proteins, with the Snf/Swi and Srb/mediator complexes.Semantic proximity Read ↗

Transcriptional activation by Gcn4p involves independent interactions with the SWI/SNF complex and the SRB/mediator.Semantic proximity Read ↗

Diverse Roles and Interactions of the SWI/SNF Chromatin Remodeling Complex Revealed Using Global ApproachesSemantic proximity Read ↗

Mutation of the SWI/SNF complex component Smarce1 decreases nucleosome stability in embryonic stem cells and impairs differentiation.Semantic proximity Read ↗

SWI/SNF-dependent chromatin remodeling of RNR3 requires TAF(II)s and the general transcription machinery.Semantic proximity Read ↗

Suppressor mutations that make the essential transcription factor Spn1/Iws1 dispensable in <i>Saccharomyces cerevisiae</i>Semantic proximity Read ↗

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Loss of Snf5 Induces Formation of an Aberrant SWI/SNF ComplexSemantic proximity Read ↗

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