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Article

Transcriptional activation by Gcn4p involves independent interactions with the SWI/SNF complex and the SRB/mediator.

Molecular cell - 1 Oct 1999

Natarajan K, Jackson B M, Zhou H, Winston F, Hinnebusch A G

Abstract excerpt

Mutations in three subunits of the SWI/SNF complex and in the Med2p subunit of the SRB/mediator of pol II holoenzyme impaired Gcn4p-activated transcription of HIS3 without reducing Gcn4p-independent transcription of this gene. Recombinant Gcn4p interacted with SWI/SNF and SRB/mediator subunits in cell extracts in a manner dependent on the same hydrophobic clusters in the Gcn4p activation domain; however, higher...

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Identifiers

PMID: 10549298
DOI: 10.1016/s1097-2765(00)80217-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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