Article
Association study of a functional catechol-O-methyltransferase genetic polymorphism with age of onset, cognitive function, symptomatology and prognosis in chronic schizophrenia.
Neuropsychobiology - 1 Jan 2004
Tsai Shih-Jen, Hong Chen-Jee, Liao Ding-Lieh, Lai I-Ching, Liou Ying-Jay
Abstract excerpt
The gene coding for catechol-O-methyltransferase (COMT), which is involved in the metabolism of catecholamines, has long been implicated as a candidate gene for schizophrenia. This study aimed to assess the relationship between a functional polymorphism (Val158Met) of the COMT gene and age of onset (AOO), symptomatology, global cognitive function and prognosis in patients with schizophrenia. The study enrolled...
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