Article
Interaction between catechol-O-methyltransferase (COMT) Val108/158Met and brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in age at onset and clinical symptoms in schizophrenia.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Feb 2007
Numata S, Ueno S, Iga J, Yamauchi K, Hongwei S, Kinouchi S, Shibuya-Tayoshi S, Tayoshi S, Aki H, Sumitani S, Itakura M, Ohmori T
Abstract excerpt
Catechol-O-methyltransferase (COMT) gene is one of the candidate genes for schizophrenia because it codes an enzyme that participates in the metabolic inactivation of dopamine and noradrenaline and a limiting factor of dopamine metabolism in the prefrontal cortex. COMT gene lies on chromosome 22q...
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