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Associations between Catechol-O-methyltransferase (COMT) polymorphisms and cognitive impairments, psychiatric symptoms and tardive dyskinesia in schizophrenia.

Brain research - 1 Mar 2024

Chi Jinghui, Ma Yanyan, Shi Menglei, Lu Chenghao, Jiang Qiaona, Li Yanzhe, Zhang Xiaofei, Shi Xiaomei, Wang Lili, Li Shen

Abstract excerpt

INTRODUCTION: Catechol-O-methyltransferase (COMT) is a crucial enzyme involved in dopamine metabolism and has been implicated in the etiology of tardive dyskinesia (TD). We aimed to investigate the associations between COMT gene polymorphisms and the occurrence and severity of TD in a Chinese population, as well as the impact on the psychiatric symptoms and cognitive impairments observed in TD patients. METHODS:...

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Identifiers

PMID: 38142723
DOI: 10.1016/j.brainres.2023.148740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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