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Article

Increased vulnerability to atrial fibrillation in transgenic mice with selective atrial fibrosis caused by overexpression of TGF-beta1.

Circulation research - 11 Jun 2004

Verheule Sander, Sato Toshiaki, Everett Thomas, Engle Steven K, Otten Dan, Rubart-von der Lohe Michael, Nakajima Hisako O, Nakajima Hidehiro, Field Loren J, Olgin Jeffrey E

Abstract excerpt

Studies on patients and large animal models suggest the importance of atrial fibrosis in the development of atrial fibrillation (AF). To investigate whether increased fibrosis is sufficient to produce a substrate for AF, we have studied cardiac electrophysiology (EP) and inducibility of atrial arrhythmias in MHC-TGFcys33ser transgenic mice (Tx), which have increased fibrosis in the atrium but not in the...

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Identifiers

PMID: 15117823
DOI: 10.1161/01.RES.0000129579.59664.9d
PMCID: PMC2129102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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