Article

Lack of authentic atrial fibrillation in commonly used murine atrial fibrillation models

2021-08-17

Abstract excerpt

The mouse is a useful preclinical species for evaluating disease etiology due to the availability of a wide variety of genetically modified strains and the ability to perform disease-modifying manipulations. In order to better characterize atrial fibrillation (AF), we profiled several commonly used murine AF models. We initially evaluated a pharmacological model of acute carbachol (CCh) treatment plus atrial burst...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5d810d70-32f6-5327-ac95-101350cc97e8
DOI: 10.1101/2021.08.17.456655

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lack of authentic atrial fibrillation in commonly used murine atrial fibrillation modelsDOI 10.1101/2021.08.17.456655Read

LKB1 knockout mouse develops spontaneous atrial fibrillation and provides mechanistic insights into human disease process.Semantic proximity Read

In vivo effect of a dominant negative Kv4.2 loss-of-function mutation eliminating I(to,f) on atrial refractoriness and atrial fibrillation in mice.Semantic proximity Read

Ventricular arrhythmogenesis: insights from murine models.Semantic proximity Read

Cardiac disease and arrhythmogenesis: Mechanistic insights from mouse modelsSemantic proximity Read

Increased vulnerability to atrial fibrillation in transgenic mice with selective atrial fibrosis caused by overexpression of TGF-beta1.Semantic proximity Read

Atrial electrophysiology and mechanisms of atrial fibrillation.Semantic proximity Read

Cardiac Arrhythmias: From (Transgenic) Mice to MenSemantic proximity Read

Arrhythmia Mechanism and Dynamics in a Humanized Mouse Model of Inherited Cardiomyopathy Caused by Phospholamban R14del Mutation.Semantic proximity Read

Electrophysiological and Structural Remodeling of the Atria in a Mouse Model of Troponin-I Mutation Linked Hypertrophic Cardiomyopathy: Implications for Atrial Fibrillation.Semantic proximity Read

Acute atrial arrhythmogenicity and altered Ca(2+) homeostasis in murine RyR2-P2328S hearts.Semantic proximity Read

Modeling Human Cardiac Arrhythmias: Insights from ZebrafishSemantic proximity Read

The Right Atrium Affects in silico Arrhythmia Vulnerability in Both AtriaSemantic proximity Read