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Article

LKB1 knockout mouse develops spontaneous atrial fibrillation and provides mechanistic insights into human disease process.

Journal of the American Heart Association - 15 Mar 2015

Ozcan Cevher, Battaglia Emily, Young Rebeccah, Suzuki Gen

Abstract excerpt

BACKGROUND: Atrial fibrillation (AF) is a complex disease process, and the molecular mechanisms underlying initiation and progression of the disease are unclear. Consequently, AF has been difficult to model. In this study, we have presented a novel transgenic mouse model of AF that mimics human disease and characterized the mechanisms of atrial electroanatomical remodeling in the genesis of AF. METHODS AND...

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Identifiers

PMID: 25773299
DOI: 10.1161/JAHA.114.001733
PMCID: PMC4392447

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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