Increased Susceptibility to Atrial Fibrillation Secondary to Atrial Fibrosis in Transgenic Goats Expressing Transforming Growth Factor-β1.

doi:10.1111/jce.13049

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Article

Increased Susceptibility to Atrial Fibrillation Secondary to Atrial Fibrosis in Transgenic Goats Expressing Transforming Growth Factor-β1.

Journal of cardiovascular electrophysiology - 1 Oct 2016

Polejaeva Irina A, Ranjan Ravi, Davies Christopher J, Regouski Misha, Hall Justin, Olsen Aaron L, Meng Qinggang, Rutigliano Heloisa M, Dosdall Derek J, Angel Nathan A, Sachse Frank B, Seidel Thomas, Thomas Aaron J, Stott Rusty, Panter Kip E, Lee Pamela M, Van Wettere Arnaud J, Stevens John R, Wang Zhongde, MacLeod Rob S, Marrouche Nassir F, White Kenneth L

Abstract excerpt

INTRODUCTION: Large animal models of progressive atrial fibrosis would provide an attractive platform to study relationship between structural and electrical remodeling in atrial fibrillation (AF). Here we established a new transgenic goat model of AF with cardiac specific overexpression of TGF-β1 and investigated the changes in the cardiac structure and function leading to AF. METHODS AND RESULTS: Transgenic...

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PMID: 27447370
DOI: 10.1111/jce.13049
PMCID: PMC5065395

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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