Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Connexin40 Mutations Slow Conduction and Increase Propensity for Atrial Fibrillation.

Heart, lung & circulation - 1 Jan 2018

Kanthan Ajita, Fahmy Peter, Rao Renuka, Pouliopoulos Jim, Alexander Ian E, Thomas Stuart P, Kizana Eddy

Abstract excerpt

BACKGROUND: Patch clamping studies using non-cardiomyocytes revealed that the human connexin40 mutations P88S, G38D, and A96S are associated with reduced gap junction conductances compared to wild type connexin40 (wtCx40). Their effects within myocytes however are unclear. We aimed to characterise P88S, G38D, and A96S after expression in rat hearts and primary cardiomyocyte cultures. METHODS: Adult Sprague-Dawley...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atrial Fibrillation
Share to Blotting, Western

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Connexins

Share to Gap Junction alpha-5 Protein

Share to Gap Junctions

Share to Myocytes, Cardiac

Share to Rats, Sprague-Dawley

Source

Identifiers

PMID: 28457700
DOI: 10.1016/j.hlc.2017.02.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Connexin40 Mutations Slow Conduction and Increase Propensity for Atrial Fibrillation.PMID 28457700Read ↗

The Connexin40A96S mutation from a patient with atrial fibrillation causes decreased atrial conduction velocities and sustained episodes of induced atrial fibrillation in mice.Semantic proximity Read ↗

Connexin40 abnormalities and atrial fibrillation in the human heartSemantic proximity Read ↗

The role of connexin40 in atrial fibrillation.Semantic proximity Read ↗

Degradation of a connexin40 mutant linked to atrial fibrillation is accelerated.Semantic proximity Read ↗

Atrial Fibrillation: Focus on Myocardial Connexins and Gap JunctionsSemantic proximity Read ↗

Association of human connexin40 gene polymorphisms with atrial vulnerability as a risk factor for idiopathic atrial fibrillation.Semantic proximity Read ↗

Electrophysiological and Structural Remodeling of the Atria in a Mouse Model of Troponin-I Mutation Linked Hypertrophic Cardiomyopathy: Implications for Atrial Fibrillation.Semantic proximity Read ↗

Gap junction alterations in human cardiac diseaseSemantic proximity Read ↗

Functional Characterization of Novel Atrial Fibrillation-Linked GJA5 (Cx40) Mutants.Semantic proximity Read ↗

Atrial tachycardia/fibrillation in the connexin 43 G60S mutant (Oculodentodigital dysplasia) mouse.Semantic proximity Read ↗

Reduced connexin40 protein expression in the right atrial appendage of patients bearing the minor connexin40 allele (-44 G --> A).Semantic proximity Read ↗

Familial hypertrophic cardiomyopathy mice display gender differences in electrophysiological abnormalities.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.