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Article

Knock-in gain-of-function sodium channel mutation prolongs atrial action potentials and alters atrial vulnerability.

Heart rhythm - 1 Dec 2010

Blana Andreas, Kaese Sven, Fortmüller Lisa, Laakmann Sandra, Damke Dierk, van Bragt Kelly, Eckstein Jens, Piccini Ilaria, Kirchhefer Uwe, Nattel Stanley, Breithardt Günter, Carmeliet Peter, Carmeliet Edward, Schotten Ulrich, Verheule Sander, Kirchhof Paulus, Fabritz Larissa

Abstract excerpt

BACKGROUND: Patients with long QT syndrome (LQTS) are at increased risk not only for ventricular arrhythmias but also for atrial pathology including atrial fibrillation (AF). Some patients with "lone" AF carry Na(+)-channel mutations. OBJECTIVE: The purpose of this study was to determine the mech...

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Source

Identifiers

PMID: 20728579
DOI: 10.1016/j.hrthm.2010.08.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20728579-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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