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Article

Eplerenone inhibits atrial fibrosis in mutant TGF-β1 transgenic mice.

Science China. Life sciences - 1 Oct 2016

Chen Xiaoqing, Zhang Wuchang, Wang Qian, Du Lili, Yi Yi, Liu Yan, Liu Xu, Duan Shengzhong

Abstract excerpt

The purpose of the present study was to study the impacts of eplerenone (EPL), an antagonist of mineralocorticoid receptors (MR), on atrial fibrosis in a mouse model with selective fibrosis in the atrium, and to explore the possible mechanisms. Using mutant TGF-β1 transgenic (Tx) mice, we first demonstrated that EPL inhibited atrial fibrosis specifically and decreased macrophage accumulation in the atria of these...

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Identifiers

PMID: 27333789
DOI: 10.1007/s11427-016-0037-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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