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Article

BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Nov 2010

Xie Yuxiang, Hayden Michael R, Xu Baoji

Abstract excerpt

Huntington's disease (HD) is caused by an expansion of the polyglutamine tract at the N terminus of huntingtin. This mutation reduces levels of BDNF in the striatum, likely by inhibiting cortical Bdnf gene expression and anterograde transport of BDNF from the cerebral cortex to the striatum. Subs...

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Identifiers

PMID: 21048129
DOI: 10.1523/JNEUROSCI.1637-10.2010
PMCID: PMC2989389

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21048129-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

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BDNF overexpression in the forebrain rescues Huntington's disease phenotypes in YAC128 mice.PMID 21048129Read ↗

Brain-derived neurotrophic factor over-expression in the forebrain ameliorates Huntington's disease phenotypes in mice.Semantic proximity Read ↗

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Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease.Semantic proximity Read ↗

Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington diseaseSemantic proximity Read ↗

Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease.Semantic proximity Read ↗

RESEARCH ARTICLE: Systematic Assessment of BDNF and Its Receptor Levels in Human Cortices Affected by Huntington's DiseaseSemantic proximity Read ↗

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease.Semantic proximity Read ↗

Relationship between BDNF expression in major striatal afferents, striatum morphology and motor behavior in the R6/2 mouse model of Huntington's disease.Semantic proximity Read ↗

Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 miceSemantic proximity Read ↗

Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington diseaseSemantic proximity Read ↗

Selective degeneration and nuclear localization of mutant huntingtin in the YAC128 mouse model of Huntington disease.Semantic proximity Read ↗

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