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Article

The neurotrophins BDNF, NT-3 and NT-4/5 promote survival and morphological and biochemical differentiation of striatal neurons in vitro.

The European journal of neuroscience - 1 Feb 1995

Ventimiglia R, Mather P E, Jones B E, Lindsay R M

Abstract excerpt

The neurotrophins, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin 4/5 (NT-4/5) and nerve growth factor (NGF), were compared for their effects on the survival and differentiation of embryonic rat striatal neurons grown in low-density cultures. Treatment with BDNF for 8 days resulted in a 40% increase in overall neuronal survival, a 3- to 5-fold increase in the number of...

Topics

Animals
Brain-Derived Neurotrophic Factor
Calbindins
Cell Differentiation
Cell Survival
Cells, Cultured
Corpus Striatum
Immunohistochemistry
Nerve Growth Factors
Nerve Tissue Proteins
Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurotrophin 3

Phenotype

Rats

S100 Calcium Binding Protein G

Source

Identifiers

PMID: 7757258
DOI: 10.1111/j.1460-9568.1995.tb01057.x

Genes

BDNF
NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7757258-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The neurotrophins BDNF, NT-3 and NT-4/5 promote survival and morphological and biochemical differentiation of striatal neurons in vitro.PMID 7757258Read ↗

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Neurotrophic‐4/5 is a survival factor for embryonic midbrain dopaminergic neurons in enriched culturesSemantic proximity Read ↗

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Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus.Semantic proximity Read ↗

Cultured basal forebrain cholinergic neurons from postnatal rats show both overlapping and non-overlapping responses to the neurotrophins.Semantic proximity Read ↗

Anterograde transport of brain-derived neurotrophic factor and its role in the brain.Semantic proximity Read ↗

Early striatal dendrite deficits followed by neuron loss with advanced age in the absence of anterograde cortical brain-derived neurotrophic factor.Semantic proximity Read ↗

The neurotrophins NT3 and BDNF induce selective specification of neuropeptide coexpression and neuronal connectivity in arcuate and periventricular hypothalamic neurons in vitro.Semantic proximity Read ↗

Up-regulation of the neuronal serotoninergic phenotype in vitro: BDNF and cAMP share Trk B-dependent mechanisms.Semantic proximity Read ↗

Neuroprotection and neuronal differentiation studies using substantia nigra dopaminergic cells derived from transgenic mouse embryos.Semantic proximity Read ↗

Neurotrophin-4/5 selectively protects nigral calbindin-containing neurons in rats with medial forebrain bundle transections.Semantic proximity Read ↗

Severe peripheral sensory neuron loss and modest motor neuron reduction in mice with combined deficiency of brain-derived neurotrophic factor, neurotrophin 3 and neurotrophin 4/5.Semantic proximity Read ↗

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