Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association with Hrs is required for the early endosomal localization, stability, and function of STAM.

Journal of biochemistry - 1 Mar 2004

Mizuno Emi, Kawahata Kensuke, Okamoto Aya, Kitamura Naomi, Komada Masayuki

Abstract excerpt

Members of the STAM family of proteins, STAM1 and STAM2, are associated with Hrs through their coiled-coil regions. Both Hrs and STAM bind ubiquitin and are involved in endosomal sorting of ubiquitinated cargo proteins for trafficking to the lysosome. Here we examined the biological significance of STAM binding to Hrs. Endogenous STAM1 and STAM2 were mostly localized on the early endosome, suggesting that they...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Down-Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endosomal Sorting Complexes Required for Transport

Share to Endosomes

Share to Epidermal Growth Factor

Share to Phosphoproteins

Share to RNA Interference

Share to Thermodynamics

Source

Identifiers

PMID: 15113837
DOI: 10.1093/jb/mvh046

Genes

STAM
STAM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association with Hrs is required for the early endosomal localization, stability, and function of STAM.PMID 15113837Read ↗

Hrs, a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2.Semantic proximity Read ↗

STAM adaptor proteins interact with COPII complexes and function in ER-to-Golgi trafficking.Semantic proximity Read ↗

Clathrin anchors deubiquitinating enzymes, AMSH and AMSH-like protein, on early endosomes.Semantic proximity Read ↗

FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes.Semantic proximity Read ↗

The Hrs/Stam complex acts as a positive and negative regulator of RTK signaling during Drosophila development.Semantic proximity Read ↗

STAM2, a member of the endosome-associated complex ESCRT-0 is highly expressed in neuronsSemantic proximity Read ↗

Spatial control of Shoc2-scaffold-mediated ERK1/2 signaling requires remodeling activity of the ATPase PSMC5.Semantic proximity Read ↗

TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation.Semantic proximity Read ↗

Structural Study of the HD-PTP Bro1 Domain in a Complex with the Core Region of STAM2, a Subunit of ESCRT-0.Semantic proximity Read ↗

A newly identified NES sequence present in spastin regulates its subcellular localization and microtubule severing activity.Semantic proximity Read ↗

Neurons and a subset of interstitial cells of Cajal in the enteric nervous system highly express Stam2 gene.Semantic proximity Read ↗

The Vps27/Hse1 complex is a GAT domain-based scaffold for ubiquitin-dependent sorting.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.