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Article

FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes.

Journal of cell science - 1 Jun 2001

Raiborg C, Bremnes B, Mehlum A, Gillooly D J, D'Arrigo A, Stang E, Stenmark H

Abstract excerpt

Hrs, an essential tyrosine kinase substrate, has been implicated in intracellular trafficking and signal transduction pathways. The protein contains several distinctive domains, including an N-terminal VHS domain, a phosphatidylinositol 3-phosphate (PtdIns(3)P)-binding FYVE domain and two coiled-coil domains. Here we have investigated the roles of these domains in the subcellular localisation of Hrs. Hrs was...

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Share to Synaptosomal-Associated Protein 25
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11493665
DOI: 10.1242/jcs.114.12.2255

Genes

EEA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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