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Article

A newly identified NES sequence present in spastin regulates its subcellular localization and microtubule severing activity.

Biochimica et biophysica acta. Molecular cell research - 1 Jan 2021

Sakoe Kumi, Shioda Norifumi, Matsuura Tohru

Abstract excerpt

Spastin, a microtubule-severing AAA ATPase, regulates microtubule dynamics and plays important roles in cell division and neurogenesis. Mutations in the spastin-coding gene SPAST lead to neurodegenerative disorders and cause spastic paraplegia type 4. Spastin has two main isoforms, M1 and M87, that differ only in the presence or absence of 86 N-terminal amino acids and have alternative splicing variants that lack...

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Identifiers

PMID: 32979422
DOI: 10.1016/j.bbamcr.2020.118862

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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