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Article

Hrs, a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2.

The Journal of biological chemistry - 18 Mar 2005

Kobayashi Hideyuki, Tanaka Nobuyuki, Asao Hironobu, Miura Shigeto, Kyuuma Masanao, Semura Kayoko, Ishii Nobuhisa, Sugamura Kazuo

Abstract excerpt

The degradation and sorting of cytoplasmic and cell-surface proteins are crucial steps in the control of cellular functions. We previously identified three mammalian Vps (vacuolar protein sorting) proteins, Hrs (hepatocyte growth factor-regulated tyrosine kinase substrate) and signal transducing adaptor molecule (STAM) 1 and -2, which are tyrosine-phosphorylated upon cytokine/growth factor stimulation. Hrs and...

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Source

Identifiers

PMID: 15640163
DOI: 10.1074/jbc.M409969200

Genes

STAM
STAM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hrs, a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2.PMID 15640163Read ↗

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