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Article

TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation.

Proceedings of the National Academy of Sciences of the United States of America - 24 Jun 2003

Lu Quan, Hope Lila Weiqiao, Brasch Michael, Reinhard Christoph, Cohen Stanley N

Abstract excerpt

Down-regulation of mitogenic signaling in mammalian cells relies in part on endosomal trafficking of activated receptors into lysosomes, where the receptors are degraded. These events are mediated by ubiquitination of the endosomal cargo and its consequent sorting into multivesicular bodies that...

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Identifiers

PMID: 12802020
DOI: 10.1073/pnas.0932599100
PMCID: PMC164637

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12802020-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation.PMID 12802020Read ↗

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Spongiform Neurodegeneration-associated E3 Ligase Mahogunin Ubiquitylates TSG101 and Regulates Endosomal TraffickingSemantic proximity Read ↗

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