Article
Roles of N-linked glycans in the recognition of microbial lipopeptides and lipoproteins by TLR2.
Cellular microbiology - 1 Jul 2006
Kataoka Hideo, Yasuda Motoaki, Iyori Mitsuhiro, Kiura Kazuto, Narita Mitsuo, Nakata Takashi, Shibata Ken-Ichiro
Abstract excerpt
Details of roles of carbohydrates attached to Toll-like receptors (TLRs) in the recognition of pathogen-associated molecular patterns and in the formation of the functional receptor complex still remain unknown. This study was designed to determine whether the glycans linked at Asn114, Asn199, Asn414 and Asn442 residues of TLR2 ectodomain were involved in the recognition of diacylated lipopeptide and lipoprotein....
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