Article
Water dynamics and dewetting transitions in the small mechanosensitive channel MscS.
Biophysical journal - 1 May 2004
Anishkin Andriy, Sukharev Sergei
Abstract excerpt
The dynamics of confined water in capillaries and nanotubes suggests that gating of ion channels may involve not only changes of the pore geometry, but also transitions between water-filled and empty states in certain locations. The recently solved heptameric structure of the small mechanosensitive channel of Escherichia coli, MscS, has revealed a relatively wide (7-15 A) yet highly hydrophobic transmembrane...
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