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Article

Selectivity mechanism of the mechanosensitive channel MscS revealed by probing channel subconducting states.

Nature communications - 1 Jan 2013

Cox C D, Nomura T, Ziegler C S, Campbell A K, Wann K T, Martinac B

Abstract excerpt

The mechanosensitive channel of small conductance (MscS) has been characterized at both functional and structural levels and has an integral role in the protection of bacterial cells against hypoosmotic shock. Here we investigate the role that the cytoplasmic domain has in MscS channel function by recording wild-type and mutant MscS single-channel activity in liposome patches. We report that MscS preferentially...

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Identifiers

PMID: 23842527
DOI: 10.1038/ncomms3137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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