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Article

Three-dimensional architecture of membrane-embedded MscS in the closed conformation.

Journal of molecular biology - 18 Apr 2008

Vásquez Valeria, Sotomayor Marcos, Cortes D Marien, Roux Benoît, Schulten Klaus, Perozo Eduardo

Abstract excerpt

The mechanosensitive channel of small conductance (MscS) is part of a coordinated response to osmotic challenges in Escherichia coli. MscS opens as a result of membrane tension changes, thereby releasing small solutes and effectively acting as an osmotic safety valve. Both the functional state depicted by its crystal structure and its gating mechanism remain unclear. Here, we combine site-directed spin labeling,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18343404
DOI: 10.1016/j.jmb.2007.10.086
PMCID: PMC2703500

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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