Article
Simulation of Drosophila circadian oscillations, mutations, and light responses by a model with VRI, PDP-1, and CLK.
Biophysical journal - 1 May 2004
Smolen Paul, Hardin Paul E, Lo Brian S, Baxter Douglas A, Byrne John H
Abstract excerpt
A model of Drosophila circadian rhythm generation was developed to represent feedback loops based on transcriptional regulation of per, Clk (dclock), Pdp-1, and vri (vrille). The model postulates that histone acetylation kinetics make transcriptional activation a nonlinear function of [CLK]. Such a nonlinearity is essential to simulate robust circadian oscillations of transcription in our model and in previous...
Topics
- Acetylation
- Animals
- Basic-Leucine Zipper Transcription Factors
- CLOCK Proteins
- Circadian Rhythm
- Computer Simulation
- DNA
- DNA-Directed RNA Polymerases
- Dose-Response Relationship, Drug
- Drosophila
- Drosophila Proteins
- Feedback, Physiological
- Gene Expression Regulation