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Article

Interlocked feedback loops within the Drosophila circadian oscillator.

Science (New York, N.Y.) - 22 Oct 1999

Glossop N R, Lyons L C, Hardin P E

Abstract excerpt

Drosophila Clock (dClk) is rhythmically expressed, with peaks in mRNA and protein (dCLK) abundance early in the morning. dClk mRNA cycling is shown here to be regulated by PERIOD-TIMELESS (PER-TIM)-mediated release of dCLK- and CYCLE (CYC)-dependent repression. Lack of both PER-TIM derepression and dCLK-CYC repression results in high levels of dClk mRNA, which implies that a separate dClk activator is present....

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Source

Identifiers

PMID: 10531060
DOI: 10.1126/science.286.5440.766

Genes

TIMELESS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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