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Article

Clockwork orange encodes a transcriptional repressor important for circadian-clock amplitude in Drosophila.

Current biology : CB - 19 Jun 2007

Lim Chunghun, Chung Brian Y, Pitman Jena L, McGill Jermaine J, Pradhan Suraj, Lee Jongbin, Keegan Kevin P, Choe Joonho, Allada Ravi

Abstract excerpt

Gene transcription is a central timekeeping process in animal clocks. In Drosophila, the basic helix-loop helix (bHLH)-PAS transcription-factor heterodimer, CLOCK/CYCLE (CLK/CYC), transcriptionally activates the clock components period (per), timeless (tim), Par domain protein 1 (Pdp1), and vrille (vri), which feed back and regulate distinct features of CLK/CYC function. Microarray studies have identified...

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Identifiers

PMID: 17555964
DOI: 10.1016/j.cub.2007.05.039
PMCID: PMC1963421

Genes

CLOCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clockwork orange encodes a transcriptional repressor important for circadian-clock amplitude in Drosophila.PMID 17555964Read ↗

CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless.Semantic proximity Read ↗

Mathematical model of the Drosophila circadian clock: loop regulation and transcriptional integration.Semantic proximity Read ↗

vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock.Semantic proximity Read ↗

Interlocked feedback loops within the Drosophila circadian oscillator.Semantic proximity Read ↗

A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless.Semantic proximity Read ↗

CRTC Potentiates Light-independent timeless Transcription to Sustain Circadian Rhythms in Drosophila.Semantic proximity Read ↗

Mammalian Period represses and de-represses transcription by displacing CLOCK-BMAL1 from promoters in a Cryptochrome-dependent manner.Semantic proximity Read ↗

Pacemaker-neuron-dependent disturbance of the molecular clockwork by a Drosophila CLOCK mutant homologous to the mouse Clock mutation.Semantic proximity Read ↗

An RNAi Screen To Identify Protein Phosphatases That Function Within the Drosophila Circadian Clock.Semantic proximity Read ↗

dCLOCK is present in limiting amounts and likely mediates daily interactions between the dCLOCK-CYC transcription factor and the PER-TIM complex.Semantic proximity Read ↗

Functional role of CREB-binding protein in the circadian clock system of Drosophila melanogaster.Semantic proximity Read ↗

Diversification of the molecular clockwork for tissue-specific function: insight from a novel Drosophila Clock mutant homologous to a mouse Clock allele.Semantic proximity Read ↗

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