Clockwork orange encodes a transcriptional repressor important for circadian-clock amplitude in Drosophila.

doi:10.1016/j.cub.2007.05.039

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Article

Clockwork orange encodes a transcriptional repressor important for circadian-clock amplitude in Drosophila.

Current biology : CB - 19 Jun 2007

Lim Chunghun, Chung Brian Y, Pitman Jena L, McGill Jermaine J, Pradhan Suraj, Lee Jongbin, Keegan Kevin P, Choe Joonho, Allada Ravi

Abstract excerpt

Gene transcription is a central timekeeping process in animal clocks. In Drosophila, the basic helix-loop helix (bHLH)-PAS transcription-factor heterodimer, CLOCK/CYCLE (CLK/CYC), transcriptionally activates the clock components period (per), timeless (tim), Par domain protein 1 (Pdp1), and vrille (vri), which feed back and regulate distinct features of CLK/CYC function. Microarray studies have identified...

Topics

Animals
Biological Clocks
Circadian Rhythm
Drosophila
Drosophila Proteins
Gene Expression Regulation
Mutation
Repressor Proteins
Transcription, Genetic

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Identifiers

PMID: 17555964
DOI: 10.1016/j.cub.2007.05.039
PMCID: PMC1963421

Genes

CLOCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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