Article
A reduced model clarifies the role of feedback loops and time delays in the Drosophila circadian oscillator.
Biophysical journal - 1 Nov 2002
Smolen Paul, Baxter Douglas A, Byrne John H
Abstract excerpt
Although several detailed models of molecular processes essential for circadian oscillations have been developed, their complexity makes intuitive understanding of the oscillation mechanism difficult. The goal of the present study was to reduce a previously developed, detailed model to a minimal representation of the transcriptional regulation essential for circadian rhythmicity in Drosophila. The reduced model...
Topics
- Algorithms
- Animals
- CLOCK Proteins
- Cell Nucleus
- Circadian Rhythm
- Cytoplasm
- Drosophila Proteins
- Drosophila melanogaster
- Feedback, Physiological
- Gene Expression Regulation
- Light
- Models, Biological
- Mutation
- Nuclear Proteins
- Oscillometry