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Article

vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock.

Cell - 7 Feb 2003

Cyran Shawn A, Buchsbaum Anna M, Reddy Karen L, Lin Meng-Chi, Glossop Nicholas R J, Hardin Paul E, Young Michael W, Storti Robert V, Blau Justin

Abstract excerpt

The Drosophila circadian clock consists of two interlocked transcriptional feedback loops. In one loop, dCLOCK/CYCLE activates period expression, and PERIOD protein then inhibits dCLOCK/CYCLE activity. dClock is also rhythmically transcribed, but its regulators are unknown. vrille (vri) and Par Domain Protein 1 (Pdp1) encode related transcription factors whose expression is directly activated by dCLOCK/CYCLE. We...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12581523
DOI: 10.1016/s0092-8674(03)00074-6

Genes

PDP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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