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Article

Mathematical model of the Drosophila circadian clock: loop regulation and transcriptional integration.

Biophysical journal - 4 Nov 2009

Fathallah-Shaykh Hassan M, Bona Jerry L, Kadener Sebastian

Abstract excerpt

Eukaryotic circadian clocks include interconnected positive and negative feedback loops. The clock-cycle dimer (CLK-CYC) and its homolog, CLK-BMAL1, are key transcriptional activators of central components of the Drosophila and mammalian circadian networks, respectively. In Drosophila, negative loops include period-timeless and vrille; positive loops include par domain protein 1. Clockwork orange (CWO) is a...

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Identifiers

PMID: 19883582
DOI: 10.1016/j.bpj.2009.08.018
PMCID: PMC2770617

Genes

BMAL1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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