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Article

The powerful neuroprotective action of C1-inhibitor on brain ischemia-reperfusion injury does not require C1q.

The American journal of pathology - 1 May 2004

De Simoni Maria Grazia, Rossi Emanuela, Storini Claudio, Pizzimenti Simone, Echart Cinara, Bergamaschini Luigi

Abstract excerpt

C1-inhibitor (C1-INH) is a major regulator of the complement classical pathway. Besides this action, it may also inhibit other related inflammatory systems. We have studied the effect of C1-INH in C57BL/6 mice with focal transient brain ischemia induced by 30 minutes of occlusion of the middle cerebral artery. C1-INH induced a dose-dependent reduction of ischemic volume that, with the dose of 15 U/mouse, reached...

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Identifiers

PMID: 15111332
DOI: 10.1016/S0002-9440(10)63744-3
PMCID: PMC1615651

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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