CB2 cannabinoid receptors modulate HIF-1α and TIM-3 expression in a hypoxia-ischemia mouse model.

doi:10.1016/j.euroneuro.2016.10.003

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Article

CB2 cannabinoid receptors modulate HIF-1α and TIM-3 expression in a hypoxia-ischemia mouse model.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Dec 2016

Kossatz Elk, Maldonado Rafael, Robledo Patricia

Abstract excerpt

The role of CB2 cannabinoid receptors (CB2R) in global brain lesions induced by hypoxia-ischemia (HI) insult is still unresolved. The aim of this study was to evaluate the involvement of CB2R in the behavioural and biochemical underpinnings related to brain damage induced by HI in adult mice, and the mechanisms involved. CB2R knockout (KO) mice and wild-type littermates (WT) underwent permanent ligation of the...

Topics

Alcohol Oxidoreductases
Animals
Behavior, Animal
Genotype
Hepatitis A Virus Cellular Receptor 2
Hypoxia-Inducible Factor 1, alpha Subunit
Hypoxia-Ischemia, Brain
Male
Mice
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Knockout

Microglia

Motor Activity

Postural Balance

Psychomotor Performance

Recognition, Psychology

Source

Open in PubMed

Identifiers

PMID: 28253997
DOI: 10.1016/j.euroneuro.2016.10.003

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