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Preconditioning with interleukin-1 alpha is required for the neuroprotective properties of mesenchymal stem cells after ischaemic stroke in mice

2022-11-17

Abstract excerpt

Mesenchymal stem cells (MSCs) pre-conditioning with interleukin-1 alpha (IL-1ɑ) drives MSCs toward a potent anti-inflammatory and pro-trophic phenotype. The aim of this study was to assess the therapeutic potential of IL-1ɑ preconditioning of MSCs, administered intra-arterially (a clinically relevant approach in the setting of thrombectomy) after experimental cerebral ischaemia in mice. Focal ischaemic stroke was...

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Literature Corpus work
8d49283c-537f-5f11-8553-d7924f6c74f6
DOI
10.21203/rs.3.rs-2263310/v1
Open publication

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Preconditioning with interleukin-1 alpha is required for the neuroprotective properties of mesenchymal stem cells after ischaemic stroke in miceDOI 10.21203/rs.3.rs-2263310/v1
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