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Article

The transcription factor interferon regulatory factor 1 is expressed after cerebral ischemia and contributes to ischemic brain injury.

The Journal of experimental medicine - 15 Feb 1999

Iadecola C, Salkowski C A, Zhang F, Aber T, Nagayama M, Vogel S N, Ross M E

Abstract excerpt

The transcription factor interferon regulatory factor 1 (IRF-1) is involved in the molecular mechanisms of inflammation and apoptosis, processes that contribute to ischemic brain injury. In this study, the induction of IRF-1 in response to cerebral ischemia and its role in ischemic brain injury were investigated. IRF-1 gene expression was markedly upregulated within 12 h of occlusion of the middle cerebral artery...

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Identifiers

PMID: 9989987
DOI: 10.1084/jem.189.4.719
PMCID: PMC2192924

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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