Article
Molecular analysis of the putative tumour-suppressor gene EXTL1 in neuroblastoma patients and cell lines.
European journal of cancer (Oxford, England : 1990) - 1 May 2004
Mathysen D, Van Roy N, Van Hul W, Laureys G, Ambros P, Speleman F, Wuyts W
Abstract excerpt
Although neuroblastoma is the most common extracranial solid tumour of childhood, little is known about its aetiology. Together with MYCN amplification and chromosome 17q gain, chromosome 1p deletion is one of the most frequently occurring genetic abnormalities in neuroblastoma. Based upon mapping of deletion breakpoints, putative tumour suppressor gene loci have been assigned to the distal part of the short arm...
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