Article
Reassignment of the EPB4.1 gene to 1p36 and assessment of its involvement in neuroblastomas.
European journal of clinical investigation - 1 Oct 2001
Huang S, Lichtenauer U D, Pack S, Wang C, Kim A C, Lutchman M, Koch C A, Torres-Cruz J, Huang S C, Benz E J, Christiansen H, Dockhorn-Dworniczak B, Poremba C, Vortmeyer A O, Chishti A H, Zhuang Z
Abstract excerpt
OBJECTIVES: EPB4.1 has been previously mapped to human chromosome 1p33-p34.2. In contradiction to this chromosomal location, we have mapped EPB4.1-1p36 by using fluorescence in situ hybridization and radiation hybrid mapping. In neuroblastomas, deletions of the telomeric end of chromosome 1 (1p36) are the most common genetic aberration. METHODS: We investigated whether genetic aberrations of EPB4.1 can be...
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