Article
Allelic deletion at chromosome bands 11q14-23 is common in neuroblastoma.
Medical and pediatric oncology - 1 Jan 2001
Maris J M, Guo C, White P S, Hogarty M D, Thompson P M, Stram D O, Gerbing R, Matthay K K, Seeger R C, Brodeur G M
Abstract excerpt
BACKGROUND: Neuroblastoma tumorigenesis may involve the differential inactivation of multiple tumor suppressor genes. Recent data have suggested that a neuroblastoma suppressor gene may be located on the long arm of chromosome 11 (11q). PROCEDURE: We therefore analyzed 295 primary neuroblastomas from a representative group of patients for loss of heterozygosity (LOH) at 25 polymorphic markers spanning 11q....
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