Article
Allelic deletion at chromosome bands 11q14-23 is common in neuroblastoma.
Medical and pediatric oncology - 1 Jan 2001
Maris J M, Guo C, White P S, Hogarty M D, Thompson P M, Stram D O, Gerbing R, Matthay K K, Seeger R C, Brodeur G M
Abstract excerpt
BACKGROUND: Neuroblastoma tumorigenesis may involve the differential inactivation of multiple tumor suppressor genes. Recent data have suggested that a neuroblastoma suppressor gene may be located on the long arm of chromosome 11 (11q). PROCEDURE: We therefore analyzed 295 primary neuroblastomas from a representative group of patients for loss of heterozygosity (LOH) at 25 polymorphic markers spanning 11q....
Topics
- Alleles
- Child
- Child, Preschool
- Chromosome Mapping
- Chromosomes, Human, Pair 1
- Chromosomes, Human, Pair 11
- Female
- Gene Deletion
- Genes, myc
- Genotype
- Humans
- Infant
- Life Tables
- Loss of Heterozygosity