Article
Genetic alterations involving chromosome 1p in children with neuroblastoma.
Israel journal of medical sciences - 1 Aug 1994
Avigad S, Tamir Y, Yaniv I, Goshen J, Kaplinsky C, Cohen I J, Zaizov R
Abstract excerpt
Neuroblastoma is a common childhood tumor of the sympathetic nervous system, characterized by N-myc amplification and loss of heterozygosity (LOH) for sequences on chromosomes 1p, 11q and 14q. Using restriction fragment length polymorphism analysis, the constitutional and tumor genotypes were compared for LOH on 1p in 25 children with neuroblastoma at diagnosis: 19 in stages III-IV, 5 in stages I-II and one in...
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