Article
Introduction of in vitro transcribed ENO1 mRNA into neuroblastoma cells induces cell death.
BMC cancer - 16 Dec 2005
Ejeskär Katarina, Krona Cecilia, Carén Helena, Zaibak Faten, Li Lingli, Martinsson Tommy, Ioannou Panayiotis A
Abstract excerpt
BACKGROUND: Neuroblastoma is a solid tumour of childhood often with an unfavourable outcome. One common genetic feature in aggressive tumours is 1p-deletion. The alpha-enolase (ENO1) gene is located in chromosome region 1p36.2, within the common region of deletion in neuroblastoma. One alternative translated product of the ENO1 gene, known as MBP-1, acts as a negative regulator of the c-myc oncogene, making the...
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